TECHNOLOGY

NanoScent has developed and designed VOCID®, a platform for Volatile Organic Compound identification to detect volatile biomarkers indicative of multiple diseases.

Introducing the VOCID® Platform

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  • NanoScent's patent-protected breakthrough technology is based on sensors capable of detecting volatile biomarkers at concentrations as low as 50 PPB. 
     

  • VOCID® can be tuned for multiple clinical applications by machine learning and hardware design.
     

  • Now being 'trained' to detect COVID-19 from breath.

The VOCID® Process

You take a breath sample, remove the safety cap and then insert it into the VOCID®. Then, the breath sample is sucked in and exposed to the sensor. Inside the VOCID® there are several components working together which then provide a result on the screen on-site.

Three Key System Components

The various parts of the platform work together to create three key system components, namely:

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  1. The pneumatic system sucks in the sample.
     

  2. An electronic computing system with algorithms to provide predictions.
     

  3. The core sensing element which is a sensor that NanoScent has developed for capturing molecules and their fingerprints

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The VOCID® Sensor

The sensor is 1cm x 1cm and on it are 12 sensing elements and each one of them is really small and has a source and a drain. Distance between them is 10 microns. What we do at NanoScent is print this on a silicon chip and add in nanoparticles. 

How do nanoparticles work?

So imagine on one side is the source and the other side the drain, in between the nanoparticles come in that are surrounded by organic compounds called ligands. These ligands are like little hairs. Now, when an organic compound comes in, these ligands move, either extracting or contracting and through this the electrical resistance pattern changes. 

 

We take this pattern and we see if it exceeds the normal threshold, for example for COVID-19 diagnostics.

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Close-up of inorganic particles on our sensors taken in the dark-field mode in the optical microscope.

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High resolution transmission electron microscopy (TEM) image of inorganic nanoparticles (NP's).

Patents

  • US20210262965A1: Particles for chemiresistor sensor

  • US20210231627A1: Sensing element for chemiresistor sensor and method of making same

  • WO2020240556A1: Method and device for identifying volatile compounds

  • WO2021111435A1: Use of a chemiresistor sensor for improving health

  • WO2021079366A1: System and method for providing and detecting volatile compounds (vcs), from liquids

  • WO2021161313A1: System and method for collecting and sensing volatile compounds

  • US20210065901A1: System and method of determining a condition of a subject based on volatile organic compounds

The information shared above is published in greater detail in our patents.